2021 Publication

Integrated analysis of source-specific risks for PM2.5-bound metals in urban, suburban, rural, and industrial areas
Hsu, CY;Chi, KH;Wu, CD;Lin, SL;Hsu, WC;Tseng, CC;Chen, MJ;Chen, YC
The levels and characteristics of atmospheric metals vary in time and location, can result in various health impacts, which increases the challenge of air quality management. We aimed to investigate PM2.5-bound metals in multiple locations and propose a methodology for comparing metal elements across study regions and prioritizing source contributions through integrated health risk assessments.(more)


Prenatal chlorpyrifos exposure in association with PPARgamma H3K4me3 and DNA methylation levels and child development
Chiu, KC;Sisca, F;Ying, JH;Tsai, WJ;Hsieh, WS;Chen, PC;Liu, CY
The aims of the study were to investigate whether prenatal chlorpyrifos exposure was associated with H3K4me3 and DNA methylation levels of the PPARγ gene in the placenta and the related effects on birth outcomes and neurodevelopment.(more)

Exposure profiles of workers from indium tin oxide target manufacturing and recycling factories in Taiwan
Hsu, YT;Su, TY;Chen, CY;Liao, HY;Kuo, YC;Wu, WT;Li, LA;Lai, CH;Liou, SH
Indium tin oxide exposure poses a potential health risk, but the exposure assessment in occupational setting remains incomplete and continues to be a significant challenge. To this end, we investigated the association of work type, airborne indium concentration, respirable fraction of total indium, and cumulative indium exposure index (CEI) with the levels of plasma indium (P–In) and urinary indium (U–In) among 302 indium tin oxide target manufacturing and recycling workers in Taiwan.(more)


Impaired response to sleep deprivation in heterozygous Disc1 mutant mice
Tsao, CY;Tuan, LH;Lee, LJ;Liu, CM;Hwu, HG;Lee, LJ
OBJECTIVES: Sleep/circadian rhythm disturbances are environmental stress factors that might interact with genetic risk factors and contribute to the pathogenesis of psychiatric disorders.(more)

Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: Multilocation analysis in 398 cities
Meng, X;Liu, C;Chen, R;Sera, F;Vicedo-Cabrera, AM;Milojevic, A;Guo, Y;Tong, S;Coelho, M;Saldiva, PHN;Lavigne, E;Correa, PM;Ortega, NV;Osorio, S;Garcia;Kyselý, J;Urban, A;Orru, H;Maasikmets, M;Jaakkola, JJK;Ryti, N;Huber, V;Schneider, A;Katsouyanni, K;Analitis, A;Hashizume, M;Honda, Y;Ng, CFS;Nunes, B;Teixeira, JP;Holobaca, IH;Fratianni, S;Kim, H;Tobias, A;Íñiguez, C;Forsberg, B;Åström, C;Ragettli, MS;Guo, YL;Pan, SC;Li, S;Bell, ML;Zanobetti, A;Schwartz, J;Wu, T;Gasparrini, A;Kan, H
OBJECTIVE: To evaluate the short term associations between nitrogen dioxide (NO(2)) and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide, using a uniform analytical protocol. DESIGN: Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis.(more)


Prediction of lumbar disc bulging and protrusion by anthropometric factors and disc morphology
Hung, IYJ;Shih, TTF;Chen, BB;Guo, YL
The relationship between reduced disc height and disc bulging and/or protrusion has been controversial. The purposes of this study were to examine the relationship between disc morphology and disc bulging and protrusion and to establish a model for predicting disc bulging and protrusion. This is a retrospective study.(more)

Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts
Wuputra, K;Tsai, MH;Kato, K;Yang, YH;Pan, JB;Ku, CC;Noguchi, M;Kishikawa, S;Nakade, K;Chen, HL;Liu, CJ;Nakamura, Y;Kuo, KK;Lin, YC;Chan, TF;Wu, DC;Hou, MF;Huang, SK;Lin, CS;Yokoyama, KK
The aryl hydrocarbon receptor (AhR) is a ligand-binding protein that responds to environmental aromatic hydrocarbons and stimulates the transcription of downstream phase I enzyme–related genes by binding the cis element of dioxin-responsive elements (DREs)/xenobiotic-responsive elements. (more)


Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells
Wang, HC;Liu, KY;Wang, LT;Hsu, SH;Wang, SC;Huang, SK
Club cells are critical in maintaining airway integrity via, in part, secretion of immunomodulatory Club cell 10 kd protein (CC10) and xenobiotic detoxification. Aryl hydrocarbon receptor (AhR) is important in xenobiotic metabolism, but its role in Club cell function is unclear. (more)

Predicting carbonaceous aerosols and identifying their source contribution with advanced approaches
Zhu, JJ;Chen, YC;Shie, RH;Liu, ZS;Hsu, CY
Organic carbon (OC) and elemental carbon (EC) play important roles in various atmospheric processes and health effects. Predicting carbonaceous aerosols and identifying source contributions are important steps for further epidemiological study and formulating effective emission control policies.(more)


Association between arsenic exposure, DNA damage, and urological cancers incidence: A long-term follow-up study of residents in an arseniasis endemic area of northeastern Taiwan
Tsai, TL;Kuo, CC;Hsu, LI;Tsai, SF;Chiou, HY;Chen, CJ;Hsu, KH;Wang, SL
Our aim was to investigate the association between arsenic exposure, DNA damage, and the incidence of bladder and kidney cancers. A total of 788 participants aged ≥40 years were enrolled in a prospective cohort study in Taiwan between 1991 and 1994, with follow-up between 2011 and 2014.(more)

Maternal proximity to petrochemical industrial parks and risk of premature rupture of membranes
Huang, CC;Pan, SC;Chin, WS;Chen, YC;Hsu, CY;Lin, PP;Guo, YL
Background Living near petrochemical industries has been reported to increase the risks of adverse birth outcomes, such as low birth weight and preterm delivery. However, evidence regarding the role of petrochemical exposure in pregnancy complications remains limited. This study evaluated the association between maternal proximity to petrochemical industrial parks (PIPs) during pregnancy and the occurrence of premature rupture of membranes (PROM).(more)


Lipid peroxidation metabolites associated with biomarkers of inflammation and oxidation stress in workers handling carbon nanotubes and metal oxide nanoparticles
Wu, WT;Jung, WT;Lee, HL
The purpose of this study was to assess the effects of lipid peroxidation with occupational exposure to different types of nanomaterials (NMs). (more)

Associations between infant developmental delays and secondhand smoke exposure modified by maternal pre-pregnancy overweight and obesity status
Wei, CF;Lin, CC;Tsai, MS;Guo, YL;Lin, SJ;Liao, HF;Hsieh, WS;Chen, MH;Chen, PC
In this study, we applied effect modification analysis for maternal pre-pregnancy weight status on detrimental neurodevelopmental effect of secondhand smoke exposure during pregnancy and infancy in a nation-wide representative population. (more)


Aryl hydrocarbon receptor is essential in the control of lung club cell homeostasis
Liu, KY;Wang, LT;Wang, HC;Wang, SN;Tseng, LW;Chai, CY;Chiou, SS;Huang, SK;Hsu, SH
BACKGROUND: Club cells play an important role in maintaining lung homeostasis and aryl hydrocarbon receptor (AhR) is known to be important in xenobiotic metabolism, but its role in regulating club cells is currently unknown.(more)

Anthropogenic perturbations to the atmospheric molybdenum cycle
Wong, MY;Rathod, SD;Marino, R;Li, LL;Howarth, RW;Alastuey, A;Alaimo, MG;Barraza, F;Carneiro, MC;Chellam, S;Chen, YC;Cohen, DD;Connelly, D;Dongarra, G;Gomez, D;Hand, J;Harrison, RM;Hopke, PK;Hueglin, C;Kuang, YW;Lambert, F;Liang, JM;Losno, R;Maenhaut, W;Milando, C;Monteiro, MIC;Morera-Gomez, Y;Querol, X;Rodriguez, S;Smichowski, P;Varrica, D;Xiao, YH;Xu, YJ;Mahowald, NM
Molybdenum (Mo) is a key cofactor in enzymes used for nitrogen (N) fixation and nitrate reduction, and the low availability of Mo can constrain N inputs, affecting ecosystem productivity. Natural atmospheric Mo aerosolization and deposition from sources such as desert dust, sea-salt spray, and volcanoes can affect ecosystem function across long timescales, but anthropogenic activities such as combustion, motor vehicles, and agricultural dust have accelerated the natural Mo cycle.(more)


Multiplexed analysis of circulating IgA antibodies for SARS-CoV-2 and common respiratory pathogens in COVID-19 patients
Fang, ZF;Sun, BQ;Zhu, AR;Lin, LC;Zhao, JC;He, S;Huang, SK;Zhong, NS;Liu, ZG
This study utilizes a protein microarray technology for simultaneous and quantitative measurements of specific IgAs for 8 different respiratory pathogens including adenovirus, respiratory syncytial virus, influenza virus type A, influenza virus type B, parainfluenza virus, mycoplasma pneumoniae, chlamydia pneumoniae and SARS-CoV-2 in serum sample of COVID-19 patients.(more)

Histological chorioamnionitis and its impact on respiratory outcome in very-low-birth-weight preterm infants
Liu, PC;Hung, YL;Shen, CM;Chen, PC;Hsieh, WS
The aim of this study was to explore the association between HCAM and neonatal respiratory outcomes in very-low-birth-weight (VLBW) preterm infants and evaluate the stepwise difference in the stage and severity of HCAM among neonatal respiratory outcomes.(more)


Effect of selected sampling media, flow rate, and time on the sampling efficiency of a liquid impinger packed with glass beads for the collection of airborne viruses
Chen, YC;Wang, IJ;Cheng, CC;Wu, YC;Bai, CH;Yu, KP
The liquid impingers can be used for sampling of viral aerosols, such as COVID-19 virus, influenza, and measles. However, the lowest cutoff diameter of commercially available liquid impingers was about 0.3 μm, and the physical collection efficiency for nano-bioaerosol is only about 10–20%. (more)


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