Maternal proximity to petrochemical industrial parks and risk of premature rupture of membranes

Maternal proximity to petrochemical industrial parks and risk of premature rupture of membranes

Environmental Research. 2021 Mar;194:Article number 110688.

Huang, CC; Pan, SC; Chin, WS; Chen, YC; Hsu, CY; Lin, PP; Guo, YL

Background: Living near petrochemical industries has been reported to increase the risks of adverse birth outcomes, such as low birth weight and preterm delivery. However, evidence regarding the role of petrochemical exposure in pregnancy complications remains limited. This study evaluated the association between maternal proximity to petrochemical industrial parks (PIPs) during pregnancy and the occurrence of premature rupture of membranes (PROM).

Results: In total, 29371 PROM cases were reported during the study period, with a corresponding 88113 healthy controls sampled. The results revealed that living within a 3-km radius of PIPs during pregnancy would increase the risk of PROM (odds ratio [OR] = 1.76, 95% CI: 1.66–1.87). Furthermore, compared with the lowest exposed group, those with high petrochemical exposure opportunity had a significantly increased risk of PROM occurrence (OR = 1.69–1.75). The adverse effects remained robust in the subgroup analysis for both term- and preterm-PROM.

Conclusion: The results of the present work provide evidence that living near PIPs during pregnancy would increase the risk of PROM, and additional studies are warranted to confirm our findings.

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