Lipid peroxidation metabolites associated with biomarkers of inflammation and oxidation stress in workers handling carbon nanotubes and metal oxide nanoparticles

Lipid peroxidation metabolites associated with biomarkers of inflammation and oxidation stress in workers handling carbon nanotubes and metal oxide nanoparticles

Nanotoxicology. 2021 Feb 11;Article in Press.

Wu, WT;Jung, WT;Lee, HL

Object: The purpose of this study was to assess the effects of lipid peroxidation with occupational exposure to different types of nanomaterials (NMs).

Results: A significant positive correlation was found between 8-isoPGF2α, 2,3 dinor-8-isoPGF2α, PGF2α, and total isoprostane in urine. Furthermore, significant positive correlations were noted between EBC 8-iso PGF2α and urinary 2,3 dinor-8-isoPGF2α (Spearman correlation r = 0.173, p = 0.035). Exposure to nano-TiO2 resulted in significantly higher levels of urinary 8-isoPGF2α, 2,3 dinor-8-and PGF2α, even after controlling for confounding factors. Moreover, significant associations and exposure intensity-response relationships between EBC 8-iso PGF2α and NMs were observed in workers, whether handling nano-TiO2, nano-SiO2, or CNTs. Among them, the significant trends were identified based on the intensity of risk levels.

Conclusion: These results provided evidence that exposure to nano-TiO2, nano-SiO2, and CNTs may lead to lipid peroxidation in EBC. For routine biomonitoring purposes, this finding, which came through non-invasive methods, may be useful for workers exposed to NMs.

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