Lipid peroxidation metabolites associated with biomarkers of inflammation and oxidation stress in workers handling carbon nanotubes and metal oxide nanoparticles
Nanotoxicology. 2021 Feb 11;Article in Press.
Wu, WT;Jung, WT;Lee, HL
Object: The purpose of this study was to assess the effects of lipid peroxidation with occupational exposure to different types of nanomaterials (NMs).
Results: A significant positive correlation was found between 8-isoPGF2α, 2,3 dinor-8-isoPGF2α, PGF2α, and total isoprostane in urine. Furthermore, significant positive correlations were noted between EBC 8-iso PGF2α and urinary 2,3 dinor-8-isoPGF2α (Spearman correlation r = 0.173, p = 0.035). Exposure to nano-TiO2 resulted in significantly higher levels of urinary 8-isoPGF2α, 2,3 dinor-8-and PGF2α, even after controlling for confounding factors. Moreover, significant associations and exposure intensity-response relationships between EBC 8-iso PGF2α and NMs were observed in workers, whether handling nano-TiO2, nano-SiO2, or CNTs. Among them, the significant trends were identified based on the intensity of risk levels.
Conclusion: These results provided evidence that exposure to nano-TiO2, nano-SiO2, and CNTs may lead to lipid peroxidation in EBC. For routine biomonitoring purposes, this finding, which came through non-invasive methods, may be useful for workers exposed to NMs.